{"id":247670,"date":"2023-10-12T08:25:47","date_gmt":"2023-10-12T15:25:47","guid":{"rendered":"https:\/\/newsforchinese.com\/v3\/?p=247670"},"modified":"2023-10-12T08:25:50","modified_gmt":"2023-10-12T15:25:50","slug":"bayer2-5%e5%84%84%e5%85%83%e6%8a%95%e8%b3%87berkeley%e8%a8%ad%e6%96%bd","status":"publish","type":"post","link":"https:\/\/newsforchinese.com\/v3\/2023\/10\/12\/bayer2-5%e5%84%84%e5%85%83%e6%8a%95%e8%b3%87berkeley%e8%a8%ad%e6%96%bd\/","title":{"rendered":"Bayer2.5\u5104\u5143\u6295\u8cc7Berkeley\u8a2d\u65bd"},"content":{"rendered":"\n<p 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2019","format":false,"excerpt":"\u4eba\u985e\u6709\u8d85\u904e10000\u7a2e\u75be\u75c5\u662f\u7531\u55ae\u500b\u57fa\u56e0\u7f3a\u9677\u5f15\u8d77\u7684\u3002\u5f9e\u7406\u8ad6\u4e0a\u8b1b\uff0c\u53ea\u8981\u6cbb\u597d\u4e86\u9019\u7a2e\u57fa\u56e0\u7f3a\u9677\uff0c\u5c0d\u61c9\u7684\u75be\u75c5\u5c31\u75ca\u7652\u4e86\u3002\u7136\u800c\uff0c\u6cbb\u597d\u57fa\u56e0\u7f3a\u9677\u53ef\u4e0d\u662f\u50cf\u8aaa\u8aaa\u90a3\u9ebc\u5bb9\u6613\u7684\u4e8b\u3002 \u4e00\u7a2e\u7a31\u70ba\u5927\u76b0\u8868\u76ae\u9b06\u89e3\u75c7\uff08epidermolysis bullosa\uff09\u7684\u7f55\u898b\u76ae\u819a\u75c5\uff0c\u8d77\u56e0\u662f\u60a3\u8005\u7f3a\u4e4f\u4e00\u7a2e\u80fd\u628a\u76ae\u819a\u7684\u5404\u500b\u5c64\u7c98\u5408\u5728\u4e00\u8d77\u7684\u95dc\u9375\u7684\u86cb\u767d\u8cea\u3002\u6c92\u6709\u9019\u7a2e\u86cb\u767d\u8cea\uff0c\u76ae\u819a\u5c31\u6703\u6495\u88c2\uff0c\u9020\u6210\u5287\u75db\u3001\u611f\u67d3\u3001\u6bc0\u5bb9\uff0c\u5728\u8a31\u591a\u60c5\u6cc1\u4e0b\u751a\u81f3\u9084\u6703\u56e0\u60e1\u6027\u76ae\u819a\u764c\u800c\u6b7b\u4ea1\u3002\u76ee\u524d\uff0cStanford\u5927\u5b78\u7684\u4e00\u500b\u5be6\u9a57\u5ba4\u5df2\u7d93\u63a1\u7528\u57fa\u56e0\u7642\u6cd5\u6210\u529f\u5730\u57f9\u80b2\u51fa\u4e00\u7247\u7247\u624b\u6a5f\u5927\u5c0f\u7684\u7c89\u7d05\u8272\u7684\u3001\u6709\u97cc\u6027\u7684\u5065\u5eb7\u76ae\u819a\uff0c\u8986\u84cb\u5728\u50b7\u53e3\u4e0a\uff0c\u4f7f\u60a3\u8005\u9577\u51fa\u81ea\u5df1\u5065\u5eb7\u7684\u76ae\u819a\u3002\u9019\u5c31\u8b49\u660e\u7d93\u904e\u6539\u9032\u7684\u57fa\u56e0\u7642\u6cd5\u5df2\u7d93\u9032\u5165\u4e86\u81e8\u5e8a\u5be6\u7528\u7684\u968e\u6bb5\u3002 \u89d2\u819c\u662f\u773c\u7403\u7684\u900f\u660e\u5916\u5c64\uff0c\u8986\u84cb\u8679\u819c\u548c\u77b3\u5b54\u3002\u4e00\u65e6\u89d2\u819c\u75c5\u8b8a\u6216\u53d7\u640d\uff0c\u60a3\u8005\u5c31\u9762\u81e8\u56b4\u91cd\u7684\u8996\u529b\u554f\u984c\uff0c\u751a\u81f3\u5931\u660e\u7684\u5371\u96aa\u3002\u7f8e\u570b\u6bcf\u5e74\u5927\u7d04\u670910\u842c\u4f8b\u89d2\u819c\u79fb\u690d\u624b\u8853\uff0c\u9700\u8981\u7528\u5c4d\u9ad4\u6350\u737b\u7684\u89d2\u819c\uff0c\u800c\u4e14\u6709\u5c07\u8fd1\u4e09\u5206\u4e4b\u4e00\u7684\u624b\u8853\u662f\u5931\u6557\u7684\u3002Stanford\u5927\u5b78\u7684\u4e00\u500b\u5be6\u9a57\u5ba4\u6b63\u5728\u57f9\u80b2\u6578\u4ee5\u767e\u842c\u8a08\u7684\u65b0\u89d2\u819c\u7d30\u80de\uff0c\u7528\u5065\u5eb7\u7684\u65b0\u7d30\u80de\u4fee\u5fa9\u75c5\u8b8a\u548c\u53d7\u640d\u7d44\u7e54\u3002\u9996\u5e2d\u7814\u7a76\u54e1Jeffrey Goldberg\u535a\u58eb\u8aaa\uff0c\u4ed6\u5011\u7528\u5f9e\u5c4d\u9ad4\u4e0a\u63d0\u53d6\u7684\u89d2\u819c\u4f5c\u70ba\u201c\u6bcd\u201d\u7d30\u80de\u57f9\u990a\u7522\u751f\u8a31\u591a\u65b0\u7684\u5e74\u8f15\u7684\u7d30\u80de\u3002\u4ed6\u5011\u7684\u5275\u65b0\u6280\u8853\u662f\u4f7f\u7528\u76f4\u5f91\u53ea\u670950\u7d0d\u7c73\u7684\u78c1\u6027\u9846\u7c92\uff08\u8a3b\uff1a\u4eba\u985e\u982d\u9aee\u7684\u76f4\u5f91\u662f75000\u7d0d\u7c73\uff09\u628a\u65b0\u57f9\u990a\u7684\u7d30\u80de\u78c1\u5316\uff1b\u7528\u6ce8\u5c04\u5668\u628a\u9019\u4e9b\u78c1\u5316\u7684\u7d30\u80de\u6ce8\u5165\u773c\u775b\uff1b\u7136\u5f8c\uff0c\u901a\u904e\u5728\u773c\u7403\u5916\u7684\u8cbc\u7247\u4e0a\u65bd\u52a0\u96fb\u78c1\u529b\uff0c\u5c07\u7d30\u80de\u62c9\u5230\u773c\u7403\u4e2d\u592e\u7684\u89d2\u819c\u5f8c\u90e8\uff1b\u96a8\u5f8c\uff0c\u78c1\u6027\u9846\u7c92\u5f9e\u7d30\u80de\u4e0a\u812b\u843d\uff0c\u96a8\u60a3\u8005\u7684\u5c3f\u6db2\u6392\u51fa\u9ad4\u5916\u3002\u9019\u7a2e\u65b9\u6cd5\u63d0\u4f9b\u4e00\u7a2e\u4ee4\u4eba\u8208\u596e\u7684\u53ef\u80fd\u6027\uff0c\u5c31\u662f\u5f9e\u4e00\u500b\u4f9b\u9ad4\u7372\u5f97\u7684\u89d2\u819c\u53ef\u4ee5\u6cbb\u7642\u5e7e\u5341\u500b\u751a\u81f3\u5e7e\u767e\u500b\u60a3\u8005\uff0c\u800c\u4e14\u53ef\u671b\u6cbb\u7642\u5176\u5b83\u8996\u7db2\u819c\u548c\u8996\u795e\u7d93\u75be\u75c5\uff0c\u5305\u62ec\u9752\u5149\u773c\u3002 Stanford\u5927\u5b78\u7814\u7a76\u5c0f\u7d44\u7684\u79fb\u690d\u8207\u5176\u5b83\u89d2\u819c\u79fb\u690d\u624b\u8853\u4e0d\u540c\u4e4b\u8655\u662f\uff0c\u5b83\u4e26\u4e0d\u9700\u8981\u6350\u8d08\u8005\u548c\u63a5\u53d7\u8005\u4e4b\u9593\u5b8c\u7f8e\u7684\u201c\u5339\u914d\u201d\uff0c\u800c\u53ea\u9700\u8981\u5c40\u90e8\u6ef4\u773c\u6db2\u5c31\u53ef\u4ee5\u9810\u9632\u6392\u65a5\u53cd\u61c9\u3002Goldberg\u535a\u58eb\u8aaa\uff0c\u4e0d\u50c5\u624b\u8853\u662f\u5b89\u5168\u7684\uff0c\u800c\u4e14\u770b\u5230\u4e86\u521d\u6b65\u7642\u6548\u7684\u8de1\u8c61\u3002\u201c\u5c0d\u6b64\u6211\u5011\u611f\u5230\u975e\u5e38\u8208\u596e\uff0c\u6211\u5011\u6301\u8b39\u614e\u6a02\u89c0\u614b\u5ea6\u3002\u201d\u4ed6\u9810\u6e2c\uff0c\u9019\u7a2e\u65b9\u6cd5\u6700\u7d42\u5c07\u53d6\u4ee3\u5927\u7d0480%\u7684\u89d2\u819c\u79fb\u690d\u3002Stanford\u5927\u5b78\u7684\u9019\u9805\u7814\u7a76\u5f97\u5230\u4e86\u7f8e\u570b\u773c\u79d1\u5b78\u6703\uff08American Academy of Ophthalmology\uff09\u7684\u652f\u6301\u3002\u7f8e\u570b\u773c\u79d1\u5b78\u6703\u81e8\u5e8a\u767c\u8a00\u4ebaPhilip R. Rizzuto\u535a\u58eb\u8aaa\uff0c\u8a72\u5b78\u6703\u652f\u6301\u5275\u65b0\u7684\u81e8\u5e8a\u7814\u7a76\u3002\u201c\u5982\u679c\u9019\u9805\u65e9\u671f\u7814\u7a76\u88ab\u8b49\u660e\u662f\u5b89\u5168\u6709\u6548\u7684\uff0c\u90a3\u9ebc\u9019\u9805\u6280\u8853\u53ef\u80fd\u6703\u5e6b\u52a9\u4e00\u4e9b\u60a3\u8005\u907f\u514d\u89d2\u819c\u79fb\u690d\u3002\u201d \u57fa\u56e0\u7642\u6cd5\u5df2\u7d93\u670920\u591a\u5e74\u7684\u6b77\u53f2\u4e86\u3002\u4f46\u662f\uff0c1999\u5e74\u5728\u7d66\u60a3\u6709\u907a\u50b3\u6027\u809d\u75c5\u7684\u4e9e\u5229\u6851\u90a3\u5dde\u5c11\u5e74Jesse Gelsinger\u690d\u5165\u77ef\u6b63\u57fa\u56e0\u7684\u6642\u5019\uff0c\u60a3\u8005\u5c0d\u4f7f\u7528\u7684\u75c5\u6bd2\u7522\u751f\u4e86\u56b4\u91cd\u53cd\u61c9\uff0c\u5c0e\u81f4\u6b7b\u4ea1\u3002\u9019\u4f7f\u57fa\u56e0\u7642\u6cd5\u906d\u5230\u4e86\u91cd\u5927\u6253\u64ca\u3002\u73fe\u5728\u4f7f\u7528\u7684\u6539\u9032\u4e86\u7684\u57fa\u56e0\u7642\u6cd5\uff0c\u5373\u7a31\u70baCRISPR\u7684\u65b0\u6280\u8853\uff0c\u5c31\u50cf\u4e00\u628a\u986f\u5fae\u93e1\u4e0b\u7684\u624b\u8853\u5200\uff0c\u4ee5\u4eba\u5011\u96e3\u4ee5\u60f3\u8c61\u7684\u7cbe\u5ea6\u3001\u6548\u7387\u548c\u5b89\u5168\u6027\u9032\u884c\u57fa\u56e0\u91cd\u7d44\u624b\u8853\u3002 Stanford\u5927\u5b78\u753151\u6b72\u7684Matthew Porteus\u535a\u58eb\u9818\u5c0e\u7684\u5718\u968a\u767c\u73fe\uff0c\u4eba\u985e\u6709\u8d85\u904e10000\u7a2e\u770b\u4e0a\u53bb\u975e\u5e38\u4e0d\u540c\u7684\u75be\u75c5\u537b\u6709\u4e00\u500b\u5171\u540c\u9ede\u2014\u2014\u5b83\u5011\u90fd\u662f\u7531\u55ae\u4e00\u7d30\u80de\u985e\u578b\u7684\u55ae\u500b\u57fa\u56e0\u7684\u55ae\u500b\u7a81\u8b8a\u5f15\u8d77\u7684\u3002\u9019\u500b\u5718\u968a\u4f7f\u7528CRISPR-Cas9\u6280\u8853\uff0c\u5229\u7528Stanford\u6821\u5712\u88e1\u7684\u7b2c\u4e00\u500b\u7d30\u80de\u88fd\u9020\u5de5\u5ee0\u7684\u7522\u54c1\u9032\u884c\u201c\u57fa\u56e0\u7de8\u8f2f\u201d\uff0c\u5c31\u662f\u5c07\u58de\u7684\u57fa\u56e0\u5207\u9664\uff0c\u7136\u5f8c\u5f15\u5165\u4e00\u500b\u597d\u7684\u57fa\u56e0\u3002\u9019\u7a2e\u65b9\u6cd5\u5df2\u7d93\u5728\u767d\u9f20\u8eab\u4e0a\u6210\u529f\u6cbb\u7642\u4e86\u4e00\u4e9b\u8840\u6db2\u75c5\uff0c\u5982\u942e\u72c0\u7d30\u80de\u8ca7\u8840\uff08sickle cell anemia\uff09\u548c\u5730\u4e2d\u6d77\u8ca7\u8840\uff08beta thalassemia\uff09\u4ee5\u53ca\u808c\u71df\u990a\u4e0d\u826f\u7b49\u5e7e\u7a2e\u7834\u58de\u514d\u75ab\u7cfb\u7d71\u7684\u75be\u75c5\u3002 \u76ee\u524d\uff0c\u4ed6\u5011\u7684\u76ee\u6a19\u662f\u81e8\u5e8a\u8a66\u9a57\u6cbb\u7642\u5169\u7a2e\u56b4\u91cd\u7684\u8840\u6db2\u75be\u75c5\u2014\u2014\u942e\u72c0\u7d30\u80de\u8ca7\u8840\u548c\u5730\u4e2d\u6d77\u8ca7\u8840\u3002\u81e8\u5e8a\u8a66\u9a57\u5206\u70ba\u5169\u500b\u968e\u6bb5\uff0c\u7b2c\u4e00\u968e\u6bb5\u4e3b\u8981\u662f\u5b89\u5168\u6027\u8a66\u9a57\uff0c\u7b2c\u4e8c\u968e\u6bb5\u91cd\u9ede\u662f\u770b\u6cbb\u7642\u6548\u679c\u3002\u4ed6\u5011\u5f9e\u60a3\u8005\u7684\u9aa8\u9ad3\u4e2d\u63d0\u53d6\u51fa\u4e00\u4e9b\u60a3\u75c5\u7684\u5e79\u7d30\u80de\uff08stem cells\uff0c\u80fd\u5920\u7522\u751f\u8840\u6db2\u6216\u514d\u75ab\u7cfb\u7d71\u7d30\u80de\uff09\u3002\u7136\u5f8c\uff0c\u60a3\u8005\u5c07\u63a5\u53d7\u9ad8\u5f37\u5ea6\u5316\u7642\uff0c\u6bba\u6b7b\u5269\u9918\u7684\u60a3\u75c5\u5e79\u7d30\u80de\uff0c\u4e26\u628a\u65b0\u7684\u3001\u5065\u5eb7\u7684\u5e79\u7d30\u80de\u6ce8\u5165\u60a3\u8005\u9ad4\u5167\u3002\u4e00\u65e6\u5065\u5eb7\u7684\u5e79\u7d30\u80de\u5230\u4f4d\uff0c\u5c31\u6703\u7522\u751f\u66f4\u591a\u5065\u5eb7\u7684\u7d30\u80de\u4f86\u53d6\u4ee3\u751f\u75c5\u7684\u7d30\u80de\u2014\u2014\u9019\u6a23\u60a3\u8005\u5c31\u6703\u75ca\u7652\u3002\u6240\u4ee5\uff0c\u4e26\u4e0d\u662f\u6240\u6709\u7684\u58de\u7d30\u80de\u90fd\u5fc5\u9808\u4fee\u5fa9\u624d\u884c\u3002 Stanford\u5927\u5b78\u5e79\u7d30\u80de\u751f\u7269\u5b78\u548c\u518d\u751f\u91ab\u5b78\u7814\u7a76\u6240\uff08Institute for Stem Cell Biology and Regenerative Medicine\uff09\u526f\u6240\u9577Maria Grazia Roncarolo\u535a\u58eb\u8aaa\uff1a\u201c\u5982\u679c\u81e8\u5e8a\u8a66\u9a57\u6210\u529f\uff0c\u5c31\u70ba\u6cbb\u7642\u8a31\u591a\u514d\u75ab\u7cfb\u7d71\u548c\u8840\u6db2\u7cfb\u7d71\u75be\u75c5\u6253\u958b\u4e86\u5927\u9580\u3002\u91ab\u5b78\u754c\u90fd\u70ba\u9019\u6a23\u7684\u6cbb\u7642\u524d\u666f\u8208\u596e\u4e0d\u5df2\uff0c\u5c24\u5176\u662f\u5728\u9019\u7a2e\u65b0\u6280\u8853\u50f9\u683c\u731b\u8dcc\u3001\u53ef\u53ca\u7bc4\u570d\u64f4\u5927\u4e4b\u969b\u3002\u201d Stanford\u5927\u5b78\u91ab\u5b78\u9662\u9662\u9577Lloyd B. 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