{"id":199771,"date":"2021-04-15T10:31:40","date_gmt":"2021-04-15T17:31:40","guid":{"rendered":"https:\/\/newsforchinese.com\/v3\/?p=199771"},"modified":"2021-04-15T10:42:13","modified_gmt":"2021-04-15T17:42:13","slug":"altrubio%e5%ae%8c%e6%88%90-6300-%e8%90%aca%e8%bc%aa%e5%8b%9f%e8%b3%87","status":"publish","type":"post","link":"https:\/\/newsforchinese.com\/v3\/2021\/04\/15\/altrubio%e5%ae%8c%e6%88%90-6300-%e8%90%aca%e8%bc%aa%e5%8b%9f%e8%b3%87\/","title":{"rendered":"ALTRUBIO\u5b8c\u6210 6,300 \u842cA\u8f2a\u52df\u8cc7"},"content":{"rendered":"\n<p>\u86fb\u8b8a\u7684\u7f8e\u570b\u5168\u5fc3\u91ab\u85e5\u751f\u6280(ALTRUBIO)\u5b8c\u6210 6,300 \u842c\u7f8e\u5143\u7684 A \u8f2a\u52df\u8cc7\u7e7c\u7e8c\u9081\u5411\u570b\u969b\u821e\u53f0\u3002<\/p>\n\n\n\n<!--more-->\n\n\n\n<p>\u4f86\u81ea\u53f0\u7063,\u4ee5\u9996\u898b\u65b0\u85e5 (First in Class) \u7814\u767c\u70ba\u4e3b\u7684\u7f8e\u570b\u5168\u5fc3\u91ab\u85e5\u751f\u6280\u80a1\u4efd\u6709\u9650\u516c\u53f8(\u201cAltruBio\u201d\u6216\u201c\u8a72\u516c\u53f8\u201d),\u4eca\u5929\u5ba3\u5e03\u5b8c\u6210 6,300 \u842c\u7f8e\u5143(\u7d04 18 \u5104\u65b0\u53f0\u5e63)\u7684 A \u8f2a\u52df\u8cc7,\u7e7c\u7e8c\u9081\u5411\u570b\u969b\u821e\u53f0\u3002 AltruBio \u65bc\u53bb\u5e74 12 \u6708\u5ba3\u4f48\u4e86\u7531 aMoon Fund \u9818\u6295\u3001BVF Partners \u5171\u540c\u53c3\u8207,\u5b8c\u6210 A \u8f2a\u7b2c\u4e00\u968e\u6bb5 3,000 \u842c\u7f8e\u5143\u7684\u52df\u8cc7,\u4e26\u8a08\u756b\u65bc\u7b2c\u4e8c\u968e\u6bb5\u6642\u518d\u52df\u8cc7 2,000 \u842c\u7f8e\u5143\u3002\u73fe\u5728\u8a72\u516c\u53f8\u8d85\u984d\u5b8c\u6210\u7b2c\u4e8c\u968e\u6bb5\u76ee\u6a19,\u7c4c\u96c6\u4e86 3,300 \u842c\u7f8e\u5143,\u4f7f A \u8f2a\u52df\u8cc7\u7e3d\u984d\u9054\u52306,300 \u842c\u7f8e\u5143\u3002\u540c\u6642\u8a72\u516c\u53f8\u70ba\u4e86\u7e7c\u7e8c\u5f37\u5316\u5176\u570b\u969b\u6a5f\u69cb\u6295\u8cc7\u8005\u80a1\u6771\u9663\u5bb9,\u65bc\u7b2c\u4e8c\u968e\u6bb5\u5f15\u5165\u6a5f\u69cb\u6295\u8cc7\u8005 CAM Capital \u53c3\u8207\u6295\u8cc7\u3002\u6b64\u8f2a\u52df\u8cc7\u5c07\u7528\u65bc\u7e7c\u7e8c\u5be6\u65bd\u65b0\u7684\u958b\u767c\u7b56\u7565,\u805a\u7126\u65bc\u91dd\u5c0d\u514d\u75ab\u75be\u75c5\u7684 PSGL-1 \u514d\u75ab\u6aa2\u67e5\u9ede\u8abf\u7bc0\u86cb\u767d (Checkpoint Regulator) \u8a08\u756b,\u5c0b\u6c42\u61c9\u7528\u5728\u591a\u7a2e\u9069\u61c9\u75c7,\u6210\u70ba\u6cbb\u7642\u5404\u7a2e\u4e0d\u540c\u514d\u75ab\u6027\u75be\u75c5\u7684\u5e73\u81fa,\u4e26\u5b8c\u6210\u516c\u53f8\u8f49\u578b\u70ba\u4e00\u5bb6\u771f\u6b63\u7684\u570b\u969b\u751f\u7269\u6280\u8853\u516c\u53f8\u3002<\/p>\n\n\n\n<figure class=\"wp-block-image size-large\"><img loading=\"lazy\" decoding=\"async\" width=\"500\" height=\"293\" data-attachment-id=\"199772\" data-permalink=\"https:\/\/newsforchinese.com\/v3\/2021\/04\/15\/altrubio%e5%ae%8c%e6%88%90-6300-%e8%90%aca%e8%bc%aa%e5%8b%9f%e8%b3%87\/altrubio\/\" data-orig-file=\"https:\/\/newsforchinese.com\/v3\/wp-content\/uploads\/2021\/04\/ALTRUBIO.jpg\" data-orig-size=\"500,293\" data-comments-opened=\"1\" data-image-meta=\"{&quot;aperture&quot;:&quot;0&quot;,&quot;credit&quot;:&quot;&quot;,&quot;camera&quot;:&quot;&quot;,&quot;caption&quot;:&quot;&quot;,&quot;created_timestamp&quot;:&quot;0&quot;,&quot;copyright&quot;:&quot;&quot;,&quot;focal_length&quot;:&quot;0&quot;,&quot;iso&quot;:&quot;0&quot;,&quot;shutter_speed&quot;:&quot;0&quot;,&quot;title&quot;:&quot;&quot;,&quot;orientation&quot;:&quot;1&quot;}\" data-image-title=\"ALTRUBIO\" data-image-description=\"\" data-image-caption=\"\" data-large-file=\"https:\/\/newsforchinese.com\/v3\/wp-content\/uploads\/2021\/04\/ALTRUBIO.jpg\" src=\"https:\/\/newsforchinese.com\/v3\/wp-content\/uploads\/2021\/04\/ALTRUBIO.jpg\" alt=\"\" class=\"wp-image-199772\" srcset=\"https:\/\/newsforchinese.com\/v3\/wp-content\/uploads\/2021\/04\/ALTRUBIO.jpg 500w, https:\/\/newsforchinese.com\/v3\/wp-content\/uploads\/2021\/04\/ALTRUBIO-300x176.jpg 300w\" sizes=\"auto, (max-width: 500px) 100vw, 500px\" \/><\/figure>\n\n\n\n<p>\u300c\u5168\u5fc3\u91ab\u85e5\u751f\u6280\u7684\u86fb\u8b8a\u662f\u4e00\u500b\u53f0\u7063\u4eba\u7684\u6545\u4e8b \u3002\u300dAltruBio \u7e3d\u88c1\u517c\u57f7\u884c\u9577\u5468\u6167\u6cc9 (Judy  Chou) \u535a\u58eb\u8868\u793a:\u300c\u5728\u904e\u53bb\u516c\u53f8\u6b77\u5e74\u4f86\u5c62\u6b21\u53d7\u5230\u7684\u6311\u6230\u4e0b,\u6211\u5011\u5f88\u9ad8\u8208\u4eca\u5929\u7531\u65bc\u65b0\u7684\u9818\u5c0e\u5718\u968a\u5e36\u52d5,\u5b8c\u6210\u4e86\u9019\u6b21\u8d85\u984d\u8a8d\u8cfc\u7684\u52df\u8cc7,\u6709\u66f4\u591a\u7684\u570b\u969b\u6295\u8cc7\u8005\u7684\u652f\u6301,\u70ba\u516c\u53f8\u672a\u4f86\u767c\u5c55\u5960\u5b9a\u66f4\u7a69\u56fa\u7684\u57fa\u790e,\u4e5f\u7d66\u4e86\u516c\u53f8\u5728\u53f0\u7063\u7814\u767c\u7684\u6210\u679c\u4e00\u500b\u5f88\u5927\u7684\u80af\u5b9a\u3002\u6211\u5011\u73fe\u5728\u64c1\u6709\u6240\u9700\u7684\u8cc7\u91d1,\u53ef\u4ee5\u5be6\u73fe\u6211\u5011\u300e\u7522\u54c1\u4e2d\u7684\u7522\u54c1\u300f(\u201cPipeline in a Product\u201d)\u7684\u9858\u666f,\u52a0\u5feb\u6211\u5011\u70ba\u591a\u7a2e\u75c5\u75c7\u7684\u75c5\u60a3\u63d0\u4f9b\u6cbb\u7642\u65b9\u6cd5\u3002 \u300d<\/p>\n\n\n\n<p>AltruBio \u5148\u5c0e\u5019\u9078\u85e5\u7269 neihulizumab \u752b\u65bc\u4eca\u5e74\u4e09\u6708\u7372\u5f97 USFDA \u5feb\u901f\u5be9\u67e5 (Fast track) \u8a8d\u5b9a,\u7528\u65bc\u6cbb\u7642\u985e\u56fa\u9187\u96e3\u6cbb\u6027\u6025\u6027\u79fb\u690d\u7269\u6297\u5bbf\u4e3b\u75c5 (SR-aGVHD) \u3002\u9019\u662f\u7531\u53f0\u7063\u958b\u5275\u51fa\u7684\u86cb\u767d\u8cea\u65b0\u85e5\u7b2c\u4e00\u6b21\u7372\u5f97 USFDA\u9019\u500b\u8a8d\u8b49\u3002\u9019\u4e9b\u7a4d\u6975\u6b63\u9762\u7684\u767c\u5c55,\u5f97\u5229\u65bc\u516c\u53f8\u904e\u53bb\u4e00\u5e74\u6240\u63a1\u53d6\u7684\u8b8a\u9769\u63aa\u65bd,\u5305\u62ec\u8058\u8acb\u570b\u969b\u516c\u8a8d\u7684\u751f\u6280\u696d\u8cc7\u6df1\u9818\u5c0e\u5c08\u5bb6\u64d4\u4efb\u65b0\u8463\u4e8b\u6703\u6210\u54e1,\u548c\u524d\u7f85\u6c0f\u6280\u8853\u71df\u904b\u7e3d\u88c1\u694a\u80b2\u6c11\u8463\u4e8b\u9577\u642d\u914d,\u4e26\u5c07\u9818\u5c0e\u6b0a\u5b8c\u5168\u4ea4\u7d66\u65b0\u8058\u7684\u7e3d\u88c1\u517c\u57f7\u884c\u9577\u5468\u6167\u6cc9\u535a\u58eb\u3002<\/p>\n\n\n\n<p>\u5468\u6167\u6cc9\u535a\u58eb\u65bc\u751f\u6280\u696d\u8cc7\u6b77\u8c50\u5bcc,\u5728\u52a0\u5165 AltruBio \u524d\u662f\u62dc\u8033\u88fd\u85e5\u751f\u6280\u71df\u904b\u7684\u5168\u7403\u7e3d\u88c1,\u5728\u85e5\u7269\u958b\u767c\u53ca\u751f\u6280\u71df\u904b\u5275\u5efa\u6709\u773e\u591a\u6210\u529f\u7d93\u9a57\u3002\u5468\u535a\u58eb\u653e\u4e0b\u5149\u74b0,\u5c07\u5979\u5728\u6b50\u7f8e\u4e8b\u696d\u7684\u6210\u5c31\u6295\u6ce8\u5728\u9019\u4e00\u500b\u4f86\u81ea\u53f0\u7063\u7684\u516c\u53f8,\u5c07\u751f\u6280\u754c\u5c0d\u5979\u7684\u6ce8\u610f\u529b\u5e36\u5230\u5168\u5fc3\u91ab\u85e5\u751f\u6280,\u4e26\u5438\u5f15\u5728\u7f8e\u570b\u7684\u7cbe\u82f1\u52a0\u5165\u57f7\u884c\u5718\u968a,\u8207\u5728\u53f0\u7063\u7684\u7814\u767c\u968a\u4f0d\u929c\u63a5,\u8de8\u8d8a\u570b\u969b\u5171\u540c\u5408\u4f5c\u3002\u5728\u5979\u7684\u9818\u5c0e\u4e0b,AltruBio \u91dd\u5c0d\u514d\u75ab\u75be\u75c5\u9818\u57df\u7684\u85e5\u7269\u958b\u767c,\u5728\u4e00\u5e74\u5167\u5f15\u8d77\u570b\u969b\u751f\u6280\u754c\u3001\u91ab\u85e5\u754c\u53ca\u91d1\u878d\u754c\u591a\u65b9\u7684\u77da\u76ee\u3002<\/p>\n\n\n\n<p>aMoon \u662f\u4e00\u5177\u9818\u5c0e\u5730\u4f4d\u7684\u91ab\u7642\u79d1\u6280\u548c\u751f\u547d\u79d1\u5b78\u5275\u6295\u57fa\u91d1,\u7e3d\u90e8\u4f4d\u65bc\u4ee5\u8272\u5217,\u7ba1\u7406\u8cc7\u7522\u8d85\u904e 11 \u5104\u7f8e\u91d1,\u662f\u4ee5\u8272\u5217\u6700\u5927\u7684\u91ab\u7642\u79d1\u6280\u5275\u6295\u57fa\u91d1\u3002 aMoon \u8207\u5091\u51fa\u7684\u4f01\u696d\u5bb6\u5408\u4f5c,\u5229\u7528\u7a81\u7834\u6027\u7684\u79d1\u5b78\u6280\u8853\u4f86\u6539\u8b8a\u91ab\u7642\u4fdd\u5065\u4e26\u52a0\u901f\u6cbb\u7652\u3002 BVF \u6210\u7acb\u65bc 1993 \u5e74,\u7e3d\u90e8\u4f4d\u65bc\u820a\u91d1\u5c71\u7063\u5340,\u662f\u516c\u8a8d\u7684\u751f\u6280\u9818\u57df\u4e2d\u6700\u8cc7\u6df1\u3001\u6700\u6210\u529f\u7684\u6a5f\u69cb\u6295\u8cc7\u8005\u4e4b\u4e00\u3002 CAM Capital \u662f\u4e00\u5bb6\u7e3d\u90e8\u4f4d\u65bc\u7d10\u7d04\u5e02\u7684\u6a5f\u69cb\u6295\u8cc7\u8005,\u5c0d\u4e0a\u5e02\u524d\u53ca\u4e0a\u5e02\u5f8c\u751f\u7269\u6280\u8853\u516c\u53f8\u6295\u8cc7\u6709\u6df1\u539a\u7d93\u9a57,\u662f\u7f8e\u570b\u6709\u540d\u7684\u8de8\u754c\u6295\u8cc7\u516c\u53f8\u3002<\/p>\n\n\n\n<p><strong>\u95dc\u65bc\u7f8e\u570b\u5168\u5fc3\u91ab\u85e5\u751f\u6280\u80a1\u4efd\u6709\u9650\u516c\u53f8(AltruBio Inc.)<\/strong><\/p>\n\n\n\n<p>\u7f8e\u570b\u5168\u5fc3\u91ab\u85e5\u751f\u6280\u80a1\u4efd\u6709\u9650\u516c\u53f8\u662f\u4e00\u5bb6\u79c1\u4eba\u751f\u7269\u6280\u8853\u516c\u53f8,\u7e3d\u90e8\u4f4d\u65bc\u820a\u91d1\u5c71\u7063\u5340,\u5b50\u516c\u53f8 (AltruBio Taiwan) \u4f4d\u65bc\u516c\u53f8\u767c\u6e90\u5730\u53f0\u5317\u5167\u6e56\u5340\u3002\u81f4\u529b\u65bc\u958b\u767c\u65b0\u578b\u514d\u75ab\u7642\u6cd5,\u7528\u65bc\u6cbb\u7642\u91ab\u7642\u9700\u6c42\u9ad8\u5ea6\u672a\u6eff\u8db3\u7684\u514d\u75ab\u6027\u75be\u75c5\u3002\u8a72\u516c\u53f8\u5229\u7528\u5176\u5c0d PSGL-1\u514d\u75ab\u6aa2\u67e5\u9ede\u8abf\u7bc0\u86cb\u767d\u4f5c\u7528\u7684\u6df1\u523b\u4e86\u89e3,\u958b\u767c\u4e86\u4e00\u500b\u6cbb\u7642 T \u7d30\u80de\u5f15\u767c\u4e4b\u514d\u75ab\u75be\u75c5\u7684\u5e73\u81fa\u3002\u5176\u5148\u5c0e\u5019\u9078\u85e5\u7269neihulizumab(AbGn-168H)\u662f\u4e00\u7a2e\u9776\u5411 PSGL-1\/CD162 \u7684\u514d\u75ab\u6aa2\u67e5\u9ede\u6fc0\u52d5\u578b\u6297\u9ad4,\u5df2\u958b\u767c\u51fa\u975c\u8108\u6ce8\u5c04\u5291\u578b,\u4e26\u5728\u56db\u7a2e\u81ea\u9ad4\u514d\u75ab\u548c\u767c\u708e\u6027\u75be\u75c5\u4e2d\u9a57\u8b49\u5176\u4f5c\u7528\u6a5f\u5236,\u76ee\u524d\u512a\u5148\u65bc\u985e\u56fa\u9187\u96e3\u6cbb\u6027\u6025\u6027\u79fb\u690d\u7269\u6297\u5bbf\u4e3b\u75c5(SR-aGVHD)\u9032\u884c\u9032\u4e00\u6b65\u7684\u81e8\u5e8a\u958b\u767c\u3002\u8a72\u516c\u53f8\u9084\u64c1\u6709\u4e00\u4e9b\u81e8\u5e8a\u524d\u958b\u767c\u968e\u6bb5\u7684\u4e0b\u4e00\u4ee3 PSGL-1 \u6297\u9ad4,\u4e3b\u8981\u81e8\u5e8a\u524d\u5019\u9078\u85e5\u7269,leiolizumab(AbGn-268),\u5df2\u7d93\u986f\u793a\u51fa\u6bd4 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\u81ea2017\u5e74\u555f\u52d5\u4e00\u9805\u96c4\u5fc3\u52c3\u52c3\u7684\u516c\u5171\u85dd\u8853\u8a08\u756b\uff0c\u76ee\u6a19\u662f\u5728\u8056\u8377\u897f\u5e02\u4e2d\u5fc3\u5efa\u9020\u9ad8\u9054200\u82f1\u5c3a\u7684\u5730\u6a19\u6027\u85dd\u8853\u88dd\u7f6e\u300cBreeze of Innovation\u300d\u3002\u7136\u800c\u6b77\u7d93\u591a\u5e74\u52df\u8cc7\u8207\u898f\u5283\uff0c\u8a72\u8a08\u756b\u81f3\u4eca\u672a\u898b\u5be6\u8cea\u9032\u5c55\uff0c\u7d44\u7e54\u8cc7\u91d1\u4e5f\u5df2\u8017\u76e1\u81f3\u50c5\u5269\u7d043.5\u842c\u7f8e\u5143\u3002 \u6839\u64da\u300aSan Jos\u00e9 Spotlight\u300b\u5831\u5c0e\uff0cUrban Confluence \u5171\u52df\u5f97\u8d85\u904e330\u842c\u7f8e\u5143\uff0c\u4f86\u81ea Adobe\u3001Kieve \u57fa\u91d1\u6703\u3001Sobrato \u5bb6\u65cf\u3001\u8056\u5854\u514b\u62c9\u62c9\u90e1\u653f\u5e9c\uff0c\u4ee5\u53ca\u73fe\u4efb\u8056\u8377\u897f\u5e02\u7b2c\u4e09\u5340\u5e02\u8b70\u54e1 Carl Salas \u7b49\u516c\u79c1\u90e8\u9580\u6350\u52a9\u8005\u3002 \u300cBreeze of 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